center for systems

& synthetic biology

an NIGMS national systems biology center


2012 UCSF iGEM team presents research on tunable bacterial symbiosis

October 19, 2012

The 2012 UCSF iGEM team recently wrapped up their summer research by presenting a poster and presentation at the iGEM America’s West Jamboree at Stanford University.

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Human genome bursts with excitement

October 16, 2012

Gene expression is thought to occur in either a constitutive or a 'bursty' manner. But does either process predominate across the human genome, and are transcription dynamics influenced by genomic position or promoter sequence?

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Engineering cell polarity

October 12, 2012

Center investigators Angi Chau, Jessica Walter, Wendell Lim and colleagues have taken a synthetic biology approach to investigate cell polarization.

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A thermodynamic memory

October 8, 2012

Biological systems are typically embedded in fluctuating surroundings. But what properties of a system make it good at harnessing energy available in its changing environment?

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CRISPR provides plug-and-play possibilities

October 1, 2012

The engineering of genetic circuits can often lead to unwanted structural interactions between the DNA, RNA, and protein components, as well as interference from host factors.

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Not all noise is created equal

September 28, 2012

Intrinsic noise in gene expression can come from two main sources: promoter fluctuations and mRNA birth/death fluctuations.

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Organelle size does matter

September 20, 2012

Learn how cells sense organelle size, as well as why such sensing is performed, in this review by Center investigators Mark Chan and Wallace Marshall published recently in Science.

What are YOU doing for science October 1-5th, 2012?

September 1, 2012

There has never been a more urgent time to advocate for science. Beyond funding, we need respect for and a real understanding of the vital role that American science must play in the 21st century.

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Center organizes team challenge workshop with Peking University

August 9, 2012

The UCSF Center for Systems & Synthetic Biology co-organized a 'team challenge' workshop with the Center for Quantitative Biology at Peking University (PKU) on July 25th-29th, 2012.

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Prioritizing posttranslational modifications

August 8, 2012

Recent advances in mass spectrometry have permitted the identification of thousands of posttranslational modifications (PTMs) including phosphorylation and ubiquitylation. But which modifications are actually biologically meaningful?  

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Turning pathogen proteins into therapeutic tools

August 6, 2012

Bacterial pathogens have evolved 'effector' proteins with very clever properties that enable the pathogen to evade host immune systems.

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Design principles from the top down

July 9, 2012

In new work published in Molecular Cell, Center investigators Nevan Krogan, Chao Tang and colleagues constructed genome-scale genetic interaction maps for the fission yeast S. pombe.

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Science and Cooking Event now available on YouTube

July 6, 2012

You can check out the news article featuring our Center's 'Science and Cooking' lecture by Professor David Weitz and Chef Corey Lee here. In case you missed the event, the article also provides links to view the lecture on YouTube.

The microbiome hits the big time

June 18, 2012

It would have been hard to miss the flood of recently published papers on the microbiome coming out in Science, Nature and elsewhere.  

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Yeast aging goes high tech

June 7, 2012

Tracking aging in individual yeast cells has been technically challenging using the traditional techniques of micromanipulation. 

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Taking interaction maps to the next level

May 1, 2012

In a recent Technology Feature in Nature, Center investigator Nevan Krogan discusses going beyond protein-protein interaction maps to extract biological meaning.  

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