center for systems

& synthetic biology

an NIGMS national systems biology center


Lei Stanley Qi receives NIH Director's Early Independence Award

October 1, 2013

Systems Biology Fellow Lei Stanley Qi was one of only 15 recipients of the prestigious 2013 NIH Director's Early Independence Awards. 

Read more ...

2013 iGEM team presents at ExplOratorium

September 6, 2013

With a kit of biological parts and new parts of their own design, the iGEM team has been working on their summer synthetic biology project for the last three months. This year their project included a strong public outreach component, which culminated with a presentation at the ExplOratorium’s After Dark event on September 5th, 2013.

Read more ...

Membrane and protein homeostasis cross paths

August 22, 2013

In new work published in Molecular Cell, Center investigator Nevan Krogan and colleagues present an E-MAP focused on S. cerevisiae genes involved in lipid metabolism.

Read more ...

Structure to systems analysis of RNA polymerase II

August 15, 2013

Center investigator Nevan Krogan and colleagues have taken E-MAP technology to the next level by examining the genetic interaction space of point mutant alleles of multifunctional genes.

Read more ...

Shining the light on complex cellular systems

August 7, 2013

In new work published in Molecular Biology of the Cell, Center investigator Chao Tang and colleagues have achieved rapid, reversible and titratable control of cellular protein localization for eight different organelles or positions within budding yeast.

Read more ...

iGEM team to be featured at ExplOratorium 'After Dark'

August 6, 2013

We know you have questions about synthetic biology. In a presentation entitled 'Micro-Transformations Can Bring Big Results', the 2013 iGEM team will be talking about their summer synthetic biology project as part of the on-going After Dark series at the San Francisco ExplOratorium.

Read more ...

Nevan Krogan appointed new director of QB3 @ UCSF

July 31, 2013

Center Investigator Nevan Krogan has been tapped to head up the California Institute for Quantitative Biosciences (QB3) at the UCSF campus.

Read more ...

UCSF again tops public institutions for bringing in NIH funding

July 17, 2013

UCSF ranked second among all institutions last year in biomedical research grants from the National Institutes of Health (NIH), and was again the top public recipient, according to an annual report by the NIH.

Read more ...

CRISPRi, the next generation

July 16, 2013

The CRISPR system has recently been shown to be a powerful tool for both genome editing and controlling gene expression. Now Systems Biology Fellow Lei Stanley Qi and colleagues take CRISPR interference (CRISPRi) further by demonstrating the use of CRISPR as a broad and modular platform for eukaryotic transcription regulation.

Read more ...

Systems biology: just another word for ecology?

July 5, 2013

How are diverse networks established, and how do they evolve in response to different environments? These are highly relevant questions for investigators focused on the field of systems biology, but are also being tackled by Deborah Gordon of Stanford University in her work on the collective behavior of ant colonies.

Read more ...

NIGMS Systems Biology Program to mark 10 year anniversary

June 27, 2013

The NIGMS National Centers for Systems Biology (NCSB) program has enabled pioneering research, training, education and outreach programs focused on systems-level inquiries of biomedical phenomena within the NIGMS mission.

Read more ...

iGEM team focuses on feeding a growing population

June 21, 2013

After two weeks of “bootcamp” and brainstorming, the 2013 UCSF iGEM team is focusing their research efforts on a synthetic biology project that will help improve the world’s food supply – specifically, crop yields.

Read more ...

UCSF hosts forward-looking symposium on cell-based therapeutics

April 24, 2013

Will cell therapies be the next frontier in pharmaceuticals, after small molecules and biologics? More than 250 people gathered at UCSF on April 12 for the first 'cell-based therapeutics: the next pillar of medicine' symposium to discuss this very topic.

Read more ...

Center trainees judge and hand out awards at local 2013 science fairs

March 25, 2013

The Synopsis Championship brings over 1000 student science fair projects to the San Jose convention Center every March to promote research in science and engineering.

Read more ...

Multicellularity discussion group launches to a standing-room-only crowd

March 12, 2013

The UCSF Center for Systems and Synthetic Biology has launched a new discussion group on the topic of "multicellular systems biology."

Read more ...

Designer ON/OFF switches using CRISPR interference

March 11, 2013

Qi et al. have developed a CRISPR interference system, referred to as CRISPRi, to turn off expression of targeted individual genes, or even sets of genes, with unprecedented simplicity and precision.

Read more ...