center for systems

& synthetic biology

an NIGMS national systems biology center


Shedding light on Ras signaling

December 9, 2013

Cellular optogenetic tools have been used to control the activity of isolated signaling proteins within living cells. In new work published in Cell, Center investigators Jared Toettcher, Wendell Lim, and colleagues now harness the power of optogenetics to track information flow from the signaling protein Ras.

By measuring dose and frequency responses in single cells, they characterize the precision, timing, and efficiency with which signals are transmitted from Ras to Erk, and couple optogenetic stimulation to proteomics to uncover how changes in signaling lead to different functional outcomes.