center for systems

& synthetic biology

an NIGMS national systems biology center


Membrane and protein homeostasis cross paths

August 22, 2013

In new work published in Molecular Cell, Center investigator Nevan Krogan and colleagues present an E-MAP focused on S. cerevisiae genes involved in lipid metabolism.

Combined with quantitative lipidomics, the authors uncover a link between protein degradation and fatty acid desaturation involving the ERAD component Ubx2p. The results implicate the existence of dedicated lipid stress responses in maintaining membrane homeostasis.