UCSF

center for systems

& synthetic biology

an NIGMS national systems biology center

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Design rules of metabolic regulatory networks

April 23, 2012


New findings by Center investigator Hao Li and colleagues suggest that many metabolic pathways in yeast share a common regulatory architecture.  Strikingly, the pathway enzyme immediately downstream of the regulatory metabolite is under the strongest transcriptional control. This general design principle for transcriptional control of a metabolic pathway can be derived from a simple cost/benefit model of gene expression, suggesting that evolution has optimized such a regulatory system. These results were recently published in PNAS.