center for systems

& synthetic biology

an NIGMS national systems biology center


Design rules of metabolic regulatory networks

April 23, 2012

New findings by Center investigator Hao Li and colleagues suggest that many metabolic pathways in yeast share a common regulatory architecture.  Strikingly, the pathway enzyme immediately downstream of the regulatory metabolite is under the strongest transcriptional control. This general design principle for transcriptional control of a metabolic pathway can be derived from a simple cost/benefit model of gene expression, suggesting that evolution has optimized such a regulatory system. These results were recently published in PNAS.