UCSF

center for systems

& synthetic biology

an NIGMS national systems biology center

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Sequestering kinases aids in detangling signaling pathways

February 21, 2013


Vidal et al., in a study published in Cell Reports, demonstrate the formation of MAPK subnuclear foci as a means to uncouple the pheromone and osmolarity signaling pathways in yeast.

Center investigator Hana El-Samad and colleagues uncover this previously undocumented spatial behavior of the MAPK proteins and suggest that transcription-factor-mediated sequestration of signaling components could serve as a general mechanism to modulate the activity of signaling pathways.