center for systems

& synthetic biology

an NIGMS national systems biology center


Prioritizing posttranslational modifications

August 8, 2012

Recent advances in mass spectrometry have permitted the identification of thousands of posttranslational modifications (PTMs) including phosphorylation and ubiquitylation. But which modifications are actually biologically meaningful?  

In new work published in Cell, Center investigators Nevan Krogan, Al Burlingame, Wendell Lim and colleagues developed a method of prioritizing PTMs, leading to predictors of functional relevance, and identification of regulatory hot spots. Further analysis of the evolution of PTM regulation suggested that only a fraction of sites are likely to have a biological role.