center for systems

& synthetic biology

an NIGMS national systems biology center


Charting new territory in HIV-human protein complexes

December 21, 2012

How does HIV rewire a host cell during the course of infection?  Identifying the hijacked proteins could lead to new drug targets to fight the virus. Now in findings published in Nature, Center investigators Nevan Krogan, Al Burlingame, and others provide the most comprehensive view to date of HIV-human protein-protein interactions, identifying 497 interactions involving 435 different human proteins. In a companion study also published in Nature, the authors analyze one of the newly identified HIV-human protein complexes in more detail. Read more