CSSB Lab Develops Novel Approach for Reactivating Latent HIV
June 20, 2014
Current antiretroviral therapies can only target viral replication, allowing HIV virus that has become latent, or transcriptionally silent, in cells to evade detection and killing. Previous methods to "reactivate" these viruses by inducing transcription have not been very effective. In a new study published today in Science. Center researcher Roy Dar, investigator Leor Weinberger, and colleagues describe a new method that takes advantage of the transcriptional noise of HIV in order to get the viruses to reveal themselves and be successfully targeted by antiretrovirals.